Carcinogen risk assessment. | Zendy

Roy E. Albert | Zendy

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Carcinogen risk assessment.

Author(s) -

Roy E. Albert

Publication year - 1989

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8981103

Subject(s) - carcinogen , carcinogenesis , risk assessment , computational biology , toxicology , chemistry , biology , cancer , computer science , genetics , biochemistry , computer security

A molecular biological rationale for the linear nonthreshold dose-response pattern for carcinogenesis is presented based on the mutagenic activation of oncogens as the basis of initiation. The approach assumes that the linear nonthreshold dose pattern at very low doses applies only to tissues that are promoted by intrinsic and extrinsic agents other than the one being modeled, and that risk is characterized on a relative rather than absolute basis in terms of aggregate tumor response.

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