Coupling growth arrest and adipocyte differentiation. | Zendy

Gérard Ailhaud | Zendy; Christian Dani | Zendy; EzZoubir Amri | Zendy; Philippe Djian | Zendy; Christian Vannier | Zendy; Alain Doglio | Zendy; Claude Forest | Zendy; D Gaillard | Zendy; Raymond Négrel | Zendy; Paola Grimaldi | Zendy

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Coupling growth arrest and adipocyte differentiation.

Author(s) -

Gérard Ailhaud,

Christian Dani,

EzZoubir Amri,

Philippe Djian,

Christian Vannier,

Alain Doglio,

Claude Forest,

D Gaillard,

Raymond Négrel,

Paola Grimaldi

Publication year - 1989

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.898017

Subject(s) - microbiology and biotechnology , adipose tissue , cellular differentiation , adipogenesis , adipocyte , biology , cell growth , mitosis , in vitro , in vivo , endocrinology , biochemistry , genetics , gene

The complete differentiation program of preadipose cells can be divided into early and late events. The expression of early markers takes place at growth arrest (G1/S boundary), whereas that of late markers, leading to terminal differentiation, takes place after a limited number of mitoses of early marker-containing cells. Only terminal differentiation requires the presence of growth hormone and triiodothyronine and results in the formation of triacylglycerol-filled, nondividing cells. The events of adipose cell differentiation which take place in vitro allow a better understanding of the development of adipose tissue in vivo.

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