Prostatic carcinogenesis evoked by cellular interaction. | Zendy

Leland W.K. Chung | Zendy; Shi Chang | Zendy; Carol Bell | Zendy; Haiyen Zhau | Zendy; Jae Y. Ro | Zendy; Andrew C. von Eschenbach | Zendy

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Prostatic carcinogenesis evoked by cellular interaction.

Author(s) -

Leland W.K. Chung,

Shi Chang,

Carol Bell,

Haiyen Zhau,

Jae Y. Ro,

Andrew C. von Eschenbach

Publication year - 1988

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.887723

Subject(s) - carcinogenesis , fibrosarcoma , stroma , carcinosarcoma , cancer research , carcinogen , prostate , prostatic adenocarcinoma , adenocarcinoma , medicine , pathology , biology , cancer , carcinoma , immunohistochemistry , genetics

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

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