Cytotoxic effects of singlet oxygen. | Zendy

Leonard J. Schiff | Zendy; Walter C. Eisenberg | Zendy; John Dziuba | Zendy; Kevin C. Taylor | Zendy; Steven Moore | Zendy

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Cytotoxic effects of singlet oxygen.

Author(s) -

Leonard J. Schiff,

Walter C. Eisenberg,

John Dziuba,

Kevin C. Taylor,

Steven Moore

Publication year - 1987

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8776199

Subject(s) - respiratory epithelium , respiratory tract , singlet oxygen , cilium , hamster , in vitro , respiratory system , oxygen , chemistry , explant culture , andrology , cytotoxic t cell , epithelium , toxicity , toxicology , pathology , biology , anatomy , medicine , microbiology and biotechnology , biochemistry , organic chemistry

The toxic effects of gas-phase singlet oxygen, 1O2, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with 1O2 showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary activity occurred at 1O2 concentrations as low as 154 ppb after a 2-hr exposure. Cytological alterations in the mucociliary epithelium were observed in explants exposed to 235 ppb 1O2 or greater. When cytotoxic effects were related to the time of exposure to 1O2, maximum effects occurred after a 4-hr exposure. In vitro recovery studies indicate that ciliary activity returned to normal between 4 and 8 hr after exposure.

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