Comparative results of 327 chemical carcinogenicity studies. | Zendy

Joseph K. Haseman | Zendy; J. E. Huff | Zendy; Errol Zeiger | Zendy; Ernest E. McConnell | Zendy

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Comparative results of 327 chemical carcinogenicity studies.

Author(s) -

Joseph K. Haseman,

J. E. Huff,

Errol Zeiger,

Ernest E. McConnell

Publication year - 1987

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8774229

Subject(s) - carcinogen , concordance , toxicology , bioinformatics , biology , genetics

The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects.

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