Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide. | Zendy

Hiroaki Kosaka | Zendy; Maki Minakawa Contributor Yasuhiro Uozumi | Zendy; Takae Nakajima | Zendy

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Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide.

Author(s) -

Hiroaki Kosaka,

Maki Minakawa Contributor Yasuhiro Uozumi,

Takae Nakajima

Publication year - 1987

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8773153

Subject(s) - n nitrosodimethylamine , escherichia coli , chemistry , nitrosamine , inhalation , enterobacteriaceae , nitrogen dioxide , sulfur dioxide , biochemistry , carcinogen , organic chemistry , medicine , anesthesia , gene

Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis was conducted with 15N-nitrosodimethylamine as an internal standard by a combination of capillary gas chromatography and mass spectrometry. Accompanying administration of cystamine increased the blood concentration of N-nitrosodimethylamine in the rabbit, suggesting inhibition of its metabolism. Concurrent sulfur trioxide inhalation increased N-nitrosodimethylamine formation in the rabbit.

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