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Teratological research using in vitro systems. V. Nonmammalian model systems.
Author(s) -
T.F.X. Collins
Publication year - 1987
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.8772237
Subject(s) - biology , vertebrate , planarian , fish <actinopterygii> , embryo , drosophila (subgenus) , zoology , computational biology , evolutionary biology , microbiology and biotechnology , genetics , fishery , regeneration (biology) , gene
In this review of alternative tests to whole-animal rodent studies, the use of sub-mammalian and sub-vertebrate systems is investigated. The history, methodology, known limitations, end points, dose response, and requirements of virus, hydra, planarian, cricket, fish, amphibia, Drosophila, and chicken embryo systems are discussed.

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