Results of in vivo and in vitro studies for assessing prenatal toxicity | Zendy

Diether Neubert | Zendy; Gudrun Blankenburg | Zendy; Ibrahim Chahoud | Zendy; Gabriele Franz | Zendy; Rainer Herken | Zendy; Michael Kästner | Zendy; Stephan Klug | Zendy; Joachim Kröger | Zendy; Ralf Krowke | Zendy; Constanze Lewandowski | Zendy; HansJoachim Merker | Zendy; Thomas Schulz | Zendy; Ralf Stahlmann | Zendy

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Results of in vivo and in vitro studies for assessing prenatal toxicity

Author(s) -

Diether Neubert,

Gudrun Blankenburg,

Ibrahim Chahoud,

Gabriele Franz,

Rainer Herken,

Michael Kästner,

Stephan Klug,

Joachim Kröger,

Ralf Krowke,

Constanze Lewandowski,

HansJoachim Merker,

Thomas Schulz,

Ralf Stahlmann

Publication year - 1986

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.867089

Subject(s) - in vivo , valproic acid , toxicity , in vitro , pharmacology , drug , chemistry , toxicology , medicine , biology , biochemistry , microbiology and biotechnology , epilepsy , psychiatry

Examples of a combined approach using in vivo as well as in vitro methods for the assessment of prenatal toxicity are presented. The topics discussed include the analysis of the possible embryotoxic potential of valproic acid (VPA), female sex hormones, bis(tri-n-butyltin) oxide (TBTO), and acyclovir and the problem of supplementing in vitro systems with drug-metabolizing activity.

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