Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust. | Zendy

C P Warren | Zendy; V. HolfordStrevens | Zendy

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Induction of histamine release in vitro from rat peritoneal mast cells by extracts of grain dust.

Author(s) -

C P Warren,

V. HolfordStrevens

Publication year - 1986

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.866655

Subject(s) - histamine , sensitization , in vitro , chemistry , mast (botany) , immunoglobulin e , mast cell , immunology , pharmacology , biology , biochemistry , antibody

The ability of extracts of grain dust and wheat to induce histamine release from rat peritoneal cells was investigated. Some grain dusts, with a high endotoxin content, were found to produce cytotoxic histamine release. Extract of wheat dust, with a low endotoxin release, produced noncytotoxic histamine release from peritoneal cells but not from purified mast cells. This reaction was dependent on the presence of phosphatidyl serine. The agent did not appear to be a lectin because histamine release was not enhanced by passive sensitization of mast cells with IgE. The activity occurred only over a narrow range of concentrations of the extract of wheat. The cause was unclear.

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