Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions. | Zendy

John A. Thomas | Zendy; David Wienckowski | Zendy; Barbara Gillies | Zendy; Michaël Thomas | Zendy; E. J. Youkilis | Zendy

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Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions.

Author(s) -

John A. Thomas,

David Wienckowski,

Barbara Gillies,

Michaël Thomas,

E. J. Youkilis

Publication year - 1986

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8665243

Subject(s) - phthalic acid , phthalate , chemistry , carcinogen , toxicology , organic chemistry , biology

A review of the literature reveals that several different phthalic acid esters (PAEs) are capable of causing testicular damage. Phthalate-induced zinc deficiency is consistent with germinal epithelial damage. Among experimental animals, mice perhaps show the greatest sensitivity to phthalate-induced terata, but high doses/exposure are required. Little toxicologic information is available with regard to phthalate-induced effects upon the neonate.

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