Activation of the Stress Axis and Neurochemical Alterations in Specific Brain Areas by Concentrated Ambient Particle Exposure with Concomitant Allergic Airway Disease | Zendy

Madhu P. Sirivelu | Zendy; Sheba M.J. MohanKumar | Zendy; James G. Wagner | Zendy; Jack R. Harkema | Zendy; P.S. MohanKumar | Zendy

Open Access

Activation of the Stress Axis and Neurochemical Alterations in Specific Brain Areas by Concentrated Ambient Particle Exposure with Concomitant Allergic Airway Disease

Author(s) -

Madhu P. Sirivelu,

Sheba M.J. MohanKumar,

James G. Wagner,

Jack R. Harkema,

P.S. MohanKumar

Publication year - 2006

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8619

Subject(s) - neurochemical , ovalbumin , medicine , endocrinology , oxidative stress , sensitization , physiology , inhalation exposure , chemistry , immunology , immune system , toxicity

Exposure to ambient particulate matter (PM) has been linked to respiratory diseases in people living in urban communities. The mechanism by which PM produces these diseases is not clear. We hypothesized that PM could act on the brain directly to stimulate the stress axis and predispose individuals to these diseases. The purpose of this study was to test if exposure to PM can affect brain areas involved in the regulation of neuroendocrine functions, especially the stress axis, and to study whether the presence of preexisting allergic airway disease aggravates the stress response.

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