Physiological aspects of free-radical reactions. | Zendy

Isao Yamazaki | Zendy; Mamoru Tamura | Zendy; R. Nakajima | Zendy; Mitsuhiro Nakamura | Zendy

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Physiological aspects of free-radical reactions.

Author(s) -

Isao Yamazaki,

Mamoru Tamura,

R. Nakajima,

Mitsuhiro Nakamura

Publication year - 1985

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8564331

Subject(s) - radical , horseradish peroxidase , enzyme , chemistry , in vivo , peroxidase , biochemistry , flavoprotein , in vitro , free radical theory of aging , metabolism , photochemistry , biophysics , biology , microbiology and biotechnology

Enzymes which catalyze the formation of free radicals in vitro will catalyze similar reactions in vivo. We believe that the formation of some kinds of free radicals has definite physiological meanings in metabolism. In this sense, the enzymes forming such free radicals are concluded to be in evolutionally advanced states. Elaborated structure and function of enzymes such as horseradish peroxidase and microsomal flavoproteins support the idea. Deleterious and side reactions caused by free radicals are assumed to be minimized in vivo by localizing the reactions, but this assumption should be verified by future studies.

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