Free-radical-mediated DNA binding. | Zendy

Peter J. O’Brien | Zendy

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Free-radical-mediated DNA binding.

Author(s) -

Peter J. O’Brien

Publication year - 1985

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8564219

Subject(s) - radical , chemistry , dna , peroxidase , trimer , biochemistry , lipid peroxidation , covalent bond , photochemistry , dimer , dna damage , reactive oxygen species , biophysics , enzyme , organic chemistry , biology

Free-radical metabolites can be generated metabolically by a one-electron reductase-catalyzed reaction or a "peroxidase" catalyzed oxidation or by photoactivation of a wide variety of aromatic xenobiotics. Radicals may also be generated during lipid peroxidation. Some radicals can react with DNA or bind covalently or noncovalently as a dismutation product or as a dimer, trimer or polymeric product. Modification to the DNA can result in single-strand breaks, loss of template activity, and crosslinking. The binding can prevent enzymic digestion. In some cases, the radicals react with oxygen, resulting before conversion to DNA reactive oxygen species. Most radicals probably do not interact with DNA.

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