Formation and persistence of arylamine DNA adducts in vivo. | Zendy

Frederick A. Beland | Zendy; Fred F. Kadlubar | Zendy

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Formation and persistence of arylamine DNA adducts in vivo.

Author(s) -

Frederick A. Beland,

Fred F. Kadlubar

Publication year - 1985

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.856219

Subject(s) - benzidine , carcinogen , chemistry , in vivo , dna , adduct , naphthylamine , dna adduct , urinary bladder , mammary gland , 2 acetylaminofluorene , biochemistry , genotoxicity , toxicity , in vitro , biology , medicine , cancer , genetics , microsome , organic chemistry , breast cancer

Aromatic amines are urinary bladder carcinogens in man and induce tumors at a number of sites in experimental animals including the liver, mammary gland, intestine, and bladder. In this review, the particular pathways involved in the metabolic activation of aromatic amines are considered as well as the specific DNA adducts formed in target and nontarget tissue. Particular emphasis is placed on the following compounds: 1-naphthylamine, 2-naphthylamine, 4-aminobiphenyl, 4-acetylaminobiphenyl, 4-acetylamino-4'-fluorobiphenyl, 3,2'-dimethyl-4-aminobiphenyl, 2-acetylaminofluorene, benzidine, N-methyl-4-aminoazobenzene, 4-aminoazobenzene, and 2-acetylaminophenanthrene.

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