Genotoxicity of glycol ethers. | Zendy

Douglas McGregor | Zendy

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Genotoxicity of glycol ethers.

Author(s) -

Douglas McGregor

Publication year - 1984

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.845797

Subject(s) - diglyme , genotoxicity , ethylene glycol , sister chromatid exchange , chemistry , ether , sperm , sister chromatids , toxicology , biology , toxicity , genetics , biochemistry , organic chemistry , in vitro , chromosome , gene , solvent

The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds. Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberrations in cultured cells. Both EGME and diglyme induced mouse sperm head morphological changes, male rat weak dominant lethal mutations and marked, but reversible, loss of male rat fertility.

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