Macrophage functions after exposure to nonfibrous mineral dusts. | Zendy

F Tilkes | Zendy; E. G. Beck | Zendy

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Macrophage functions after exposure to nonfibrous mineral dusts.

Author(s) -

F Tilkes,

E. G. Beck

Publication year - 1983

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8351167

Subject(s) - toxicity , chemistry , lactic acid , lactate dehydrogenase , albumin , bovine serum albumin , biochemistry , biology , bacteria , enzyme , genetics , organic chemistry

The effects of the standard dusts, electrocorundum, and Dorentruper quartz (DQ12), as well as mine dusts have been tested in guinea pig lung macrophage cultures. The parameters compared were: release of lactic dehydrogenase for demonstration of plasma membrane permeability and production of lactic acid as an indicator of carbohydrate metabolism. In addition to the dose-dependent toxicity of different mine, coal and other mineral dusts, we studied the influence of cell culture media and the supplement of fetal calf serum (FCS) and bovine serum albumin (BSA) upon the cell toxicity in this test system. We demonstrated a protective effect of FCS and BSA on dusts of low and medium toxicity, while dusts of high toxicity, like DQ12, were not influenced in their toxicity.

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