Fibroblast RNA and macrophage proteins (including the fibrogenic factor) in experimental silicosis. | Zendy

E. Kulonen | Zendy; M. Aalto | Zendy; Sirpa Aho | Zendy; Pirjo Lehtinen | Zendy; M. Potila | Zendy

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Fibroblast RNA and macrophage proteins (including the fibrogenic factor) in experimental silicosis.

Author(s) -

E. Kulonen,

M. Aalto,

Sirpa Aho,

Pirjo Lehtinen,

M. Potila

Publication year - 1983

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8351119

Subject(s) - macrophage , silicosis , fibroblast , ribonuclease , rna , chemistry , alveolar macrophage , lung , basic fibroblast growth factor , protein biosynthesis , messenger rna , microbiology and biotechnology , biochemistry , biology , growth factor , pathology , medicine , in vitro , gene , receptor

A hypothesis is presented for the action of silica-treated macrophages on protein synthesis in fibroblasts and also a method for the isolation of silica-attached materials in lung tissue. The increased protein synthesis in the fibroblasts is due, at least partly, to an increase in mRNA. Silica prevents the suppressing "macrophage effect" of macrophage-originated ribonuclease on fibroblasts. However, under certain conditions, collagen synthesis is stimulated by silica-treated macrophage preparations to such an extent that the effect cannot be explained by the inhibition of macrophage ribonuclease alone. We therefore postulate the existence of a fibrogenic factor, which is released by the macrophages. This factor has been demonstrated and can be purified from lung homogenate of SiO2-treated rats.

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