In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat. | Zendy

Michael S. Nussbaum | Zendy; Emerich S. Fiala | Zendy; Bharati Kulkarni | Zendy; Karam ElBayoumy | Zendy; J. H. Weisburger | Zendy

Open Access

In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.

Author(s) -

Michael S. Nussbaum,

Emerich S. Fiala,

Bharati Kulkarni,

Karam ElBayoumy,

J. H. Weisburger

Publication year - 1983

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8349223

Subject(s) - carcinogen , metabolite , in vivo , glucuronide , hamster , urine , golden hamster , metabolism , chemistry , carcinogenesis , pharmacology , excretion , biochemistry , biology , endocrinology , genetics , gene

The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesions. Evidence was obtained for the presence of the N-hydroxy-N-glucuronide of DMAB as a major metabolite in hamster urine and bile and in rat bile but not urine. The routes of excretion of this metabolite, which may represent a transport form of the ultimate carcinogen, correlate well with the main tumor sites in the two species. Other metabolites partially identified were the sulfates and glucuronides of C-hydroxylated DMAB and C-hydroxylated-N-acetyl DMAB.

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