Open AccessMitochondrial toxicity of phthalate esters.
Author(s) -
Ronald L. Melnick,
Carol M. Schiller
Publication year - 1982
Publication title -
environmental health perspectives
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.824551
Subject(s) - phthalate , dibutyl phthalate , chemistry , diethyl phthalate , dimethyl phthalate , reductase , oxidative phosphorylation , phthalic acid , succinate dehydrogenase , biochemistry , mitochondrion , enzyme , organic chemistry
The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-n-butyl phthalate had a moderate effect on energy coupling and di(2-ethylhexyl) phthalate had no apparent effect. The potency of inhibition of succinate cytochrome c reductase activity was mono(2-ethylhexyl) phthalate greater than di-n-butyl phthalate greater than mono-n-butyl phthalate = di(2-ethylhexyl) phthalate. It is concluded that phthalate esters affect mitochondrial activities by altering the permeability properties of the inner membrane and by inhibiting succinate dehydrogenase activity.