New approaches to immunotoxicity testing. | Zendy

Douglas L. Archer | Zendy

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New approaches to immunotoxicity testing.

Author(s) -

Douglas L. Archer

Publication year - 1982

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8243109

Subject(s) - in vitro , in vivo , in vitro toxicology , function (biology) , adoptive cell transfer , immunology , biology , computational biology , microbiology and biotechnology , biochemistry , cytotoxic t cell

New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for an in vitro metabolic activation step coupled to other in vitro immunologic assays is discussed.

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