Limitations on dose estimation. | Zendy

Nurtan A. Esmen | Zendy

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Limitations on dose estimation.

Author(s) -

Nurtan A. Esmen

Publication year - 1981

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.81423

Subject(s) - estimation , extrapolation , process (computing) , computer science , hazardous waste , construct (python library) , set (abstract data type) , econometrics , statistics , mathematics , biology , engineering , ecology , systems engineering , programming language , operating system

The process of estimation of dose at a target organ from the measurements of environmental concentration of potentially hazardous agents is theoretically examined. The analysis of the estimation process suggests that the design of any study which aims to find the health effects of an agent or to construct a dose-response relationship from environmental measurements must be fully scrutinized to see whether a representative dose is tractable from such measurements made on the agent or extrapolation from a set of known effects at high dose levels is feasible and desirable.

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