Open AccessMutagenicity studies of vinyl chloride.
Author(s) -
Jill D. Fabricant,
Marvin S. Legator
Publication year - 1981
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.8141189
Subject(s) - vinyl chloride , somatic cell , in vivo , in vitro , biology , chemistry , toxicology , genetics , biochemistry , gene , organic chemistry , copolymer , polymer
Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.
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