Review of pulmonary effects of poly(vinyl chloride) and vinyl chloride exposure. | Zendy

Ruth Lilis | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Review of pulmonary effects of poly(vinyl chloride) and vinyl chloride exposure.

Author(s) -

Ruth Lilis

Publication year - 1981

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8141167

Subject(s) - vinyl chloride , pulmonary fibrosis , inhalation , carcinogen , lung , medicine , lung cancer , pathology , fibrosis , chemistry , biochemistry , anesthesia , polymer , organic chemistry , copolymer

The contributions of several recent reports to the definition of pulmonary effects of PVC dust inhalation are reviewed. Granulomatous reaction, with inclusion of PVC particles in macrophages and histocytes, and associated interstitial pulmonary fibrosis have been found to lead to exertional dyspnoea, diffuse micronodular chest radiographic opacities and restrictive pulmonary dysfunction. The effects of vinyl chloride (VC) monomer (gas) on proteins and the immunologic mechanisms triggered by the altered protein are possible mechanisms for the development in some cases of interstitial pulmonary fibrosis secondary to VC exposure. Vinyl chloride, a confirmed carcinogen, has been associated with, among other malignant tumors, a significant increase in the incidence of lung cancer. The magnitude of this effect has not yet been completely evaluated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research