PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter. | Zendy

J E Trosko | Zendy; Betty Dawson | Zendy; ChiaChe Chang | Zendy

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PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

Author(s) -

J E Trosko,

Betty Dawson,

ChiaChe Chang

Publication year - 1981

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8137179

Subject(s) - chinese hamster , in vitro , carcinogen , hamster , cell culture , metabolic pathway , biology , cell , polychlorinated biphenyl , chinese hamster ovary cell , microbiology and biotechnology , metabolism , genetics , chemistry , cancer research , biochemistry , toxicology , environmental chemistry

Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter.

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