Ecotoxicology of phenylphosphonothioates. | Zendy

B. Magnus Francis | Zendy; Loren Hansen | Zendy; T. R. Fukuto | Zendy; P Y Lu | Zendy; Robert L. Metcalf | Zendy

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Ecotoxicology of phenylphosphonothioates.

Author(s) -

B. Magnus Francis,

Loren Hansen,

T. R. Fukuto,

P Y Lu,

Robert L. Metcalf

Publication year - 1980

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.8036187

Subject(s) - bioaccumulation , metabolite , acute toxicity , ecotoxicology , toxicology , toxicity , environmental chemistry , neurotoxicity , chemistry , biology , endocrinology , organic chemistry

The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with sigma sigma of the substituted phenyl group (regression coefficient r = -0.91) while acute toxicity to mammals was slightly less well correlated (regression coefficient r = -0.71), and neurotoxicity was poorly correlated with sigma sigma (regression coefficient r = -0.35). Both EPN and leptophos were markedly more persistent and bioaccumulative in the model ecosystem than parathion. Desbromoleptophos, a contaminant and metabolite of leptophos, was seen to be a highly stable and persistent terminal residue of leptophos.

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