Effect of toxaphene on pyruvic and lactic acid levels in the rat. | Zendy

David B. Peakall | Zendy

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Effect of toxaphene on pyruvic and lactic acid levels in the rat.

Author(s) -

David B. Peakall

Publication year - 1979

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.793097

Subject(s) - toxaphene , pyruvic acid , lactic acid , chemistry , lactic dehydrogenase , biochemistry , biology , pesticide , enzyme , bacteria , genetics , agronomy

Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid dehydrogenase induced by toxaphene do not give rise to physiological changes in unstressed rats.

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