Assessment of testicular toxicity in laboratory animals | Zendy

Ralph Heywood | Zendy; R.W. James | Zendy

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Assessment of testicular toxicity in laboratory animals

Author(s) -

Ralph Heywood,

R.W. James

Publication year - 1978

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.782473

Subject(s) - spermatogenesis , toxicity , reproductive toxicity , testicular atrophy , testicle , andrology , biology , atrophy , epithelium , fertility , hormone , physiology , endocrinology , medicine , population , genetics , environmental health

The currently available methods of assessing testicular toxicity and fertility are discussed. Compounds inducing testicular atrophy mainly affect the seminiferous epithelium, with progressive loss of spermatozoa, spermatids, spermatocytes, and spermatogonia. Quantitative histometric analysis of spermatogenesis, together with hormone assays, could be used to advantage in defining the underlying mechanisms of toxicity.

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