Open AccessMetabolism and biochemical toxicity of PCBs and PBBs
Author(s) -
H.B. Matthews,
George F. Fries,
Albert M Gardner,
Larry H. Garthoff,
Jorge Goldstein,
Yang Gyu Ku,
John Moore
Publication year - 1978
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.7824147
Subject(s) - polybrominated biphenyls , polychlorinated dibenzofurans , environmental chemistry , polybrominated diphenyl ethers , blubber , polychlorinated dibenzodioxins , pollutant , chemistry , toxicology , biology , zoology , organic chemistry
One of the major biochemical effects of PCBs is the induction of microsomal enzymes in the liver. Risebrough et al. (1) suggested that PCBs have the capability to induce the activities of microsomal enzymes. Subsequently, Street et al. (2), demonstrated the induction of liver enzymes in rats by PCBs. Since then, a great number of articles have been published on this subject. The enzyme systems studied have included mainly hydroxylases, Nand O-demethylases and nitroreductases, and to a lesser extent nonspecific carboxylesterase, bromosulfophthalein-glutathione conjugating enzyme, p-nitrophenol UDP-glucuronyl transferase and EPN-detoxification systems. The induction of microsomal enzymes by commercial PCBs has been demonstrated perorally in rabbits (3) rats (4) and primates (5) and via intraperitoneal injection (6) and skin application in rats (7). Values reported for the threshold of enzyme induction by PCBs vary between 0.5 and 25 ppm (3, 8, 9) (et al., 1974). The time course of microsomal enzyme induction was studied by Litterst et al. in rats (10). They
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom