Effect of enzyme induction on nephrotoxicity of halothane-related compounds. | Zendy

Ben A. Hitt | Zendy; Richard I. Mazze | Zendy

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Effect of enzyme induction on nephrotoxicity of halothane-related compounds.

Author(s) -

Ben A. Hitt,

Richard I. Mazze

Publication year - 1977

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7721179

Subject(s) - methoxyflurane , halothane , enflurane , isoflurane , anesthetic , enzyme inducer , chemistry , nephrotoxicity , fluoride , pharmacology , in vivo , tabun , phenobarbital , enzyme , enzyme assay , anesthesia , biochemistry , medicine , toxicity , biology , soman , organic chemistry , inorganic chemistry , acetylcholinesterase , microbiology and biotechnology

Nephrotoxicity following administration of methoxyflurane has been shown to be directly related to anesthetic metabolism to inorganic fluoride. Enzyme induction should increase metabolic rate and the amount of inorganic fluoride that is released. In vivo studies in Fischer 344 rats show that enzyme induction with phenobarbital or phenytoin increases defluorination following methoxyflurane anesthesia but not after enflurane or isoflurane. In vitro, methoxyflurane defluorinase activity was increased far more than that of any of the other anesthetics. These data suggest that treatment with enzyme inducing drugs increases the risk of nephrotoxocity only if methoxyflurane is the anesthetic agent.

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