Effect of various treatments on toxicity of inhaled vinylidene chloride. | Zendy

Robert D. Short | Zendy; Joseph M. Winston | Zendy; Jan L. Minor | Zendy; Joseph Seifter | Zendy; C C Lee | Zendy

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Effect of various treatments on toxicity of inhaled vinylidene chloride.

Author(s) -

Robert D. Short,

Joseph M. Winston,

Jan L. Minor,

Joseph Seifter,

C C Lee

Publication year - 1977

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7721125

Subject(s) - disulfiram , toxicity , pharmacology , chemistry , acute toxicity , inhalation , median lethal dose , chloride , acute exposure , kidney , toxicology , medicine , biology , anesthesia , organic chemistry

The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC. Treatment with diethyldithiocarbamate and thiram also protected mice from the acute lethal effects of VDC.

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