Pharmacokinetic models for lipophilic compounds. | Zendy

H.B. Matthews | Zendy; D.B. Tuey | Zendy; M. Anderson | Zendy

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Pharmacokinetic models for lipophilic compounds.

Author(s) -

H.B. Matthews,

D.B. Tuey,

M. Anderson

Publication year - 1977

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7720257

Subject(s) - pharmacokinetics , disposition , physiologically based pharmacokinetic modelling , xenobiotic , pharmacology , toxicokinetics , polychlorinated biphenyl , bioavailability , environmental chemistry , chemistry , medicine , psychology , biochemistry , social psychology , enzyme

In many instances pharmacokinetic modeling offers the best method of interpreting the significance to man of results obtained with laboratory animals but first we must have accurate models for our laboratory animals. A physiological pharmacokinetic model has been used to simulate the disposition of polychlorinated biphenyls (PCBs) in the rat and to extrapolate results obtained with the rat to predict the disposition of PCBs in the mouse. The modeling methods have also been extended to predict the disposition of a polybrominated biphenyl (PBB) in the rat following IV, oral, and multiple oral doses. It is anticipated that with additional experience and work a physiological pharmacokinetic model can be used to predict the disposition of these and other xenobiotics in man.

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