Mutagenicity and metabolism of vinyl chloride and related compounds. | Zendy

Helmut Bartsch | Zendy; C. Malaveille | Zendy; A. Barbin | Zendy; Henriette Brésil | Zendy; Lorenzo Tomatis | Zendy; Ruggero Montesano | Zendy

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Mutagenicity and metabolism of vinyl chloride and related compounds.

Author(s) -

Helmut Bartsch,

C. Malaveille,

A. Barbin,

Henriette Brésil,

Lorenzo Tomatis,

Ruggero Montesano

Publication year - 1976

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7617193

Subject(s) - vinyl chloride , chemistry , metabolism , enzyme , biochemistry , microsome , electrophile , chloride , hamster , in vitro , biotransformation , organic chemistry , biology , catalysis , microbiology and biotechnology , copolymer , polymer

The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites. The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Hepatic microsomal mixed function oxidases from rats, mice, and humans were equally effective in transforming vinyl chloride into alkylating agents in vitro. Two of the enzyme reaction products, i.e., chloroethylene oxide and 2-chloroacetaldehyde, showed potent genetic activity in microorganisms and Chinese hamster V79 cells. The role of liver microsomal enzymes in the generation of electrophilic mutagenic vinyl chloride metabolites is discussed.

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