Effect of nickel chloride on primary antibody production in the spleen. | Zendy

J.A. Graham | Zendy; D. E. Gardner | Zendy; Frederick J. Miller | Zendy; Mary J. Daniels | Zendy; David L. Coffin | Zendy

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Effect of nickel chloride on primary antibody production in the spleen.

Author(s) -

J.A. Graham,

D. E. Gardner,

Frederick J. Miller,

Mary J. Daniels,

David L. Coffin

Publication year - 1975

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7512109

Subject(s) - spleen , nickel , chemistry , antibody , chloride , immunology , peripheral blood mononuclear cell , endocrinology , medicine , toxicology , biochemistry , biology , in vitro , organic chemistry

Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05).

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