Metabolism and toxicity of styrene. | Zendy

Kenneth C. Leibman | Zendy

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Metabolism and toxicity of styrene.

Author(s) -

Kenneth C. Leibman

Publication year - 1975

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7511115

Subject(s) - biotransformation , styrene , toxicity , metabolism , chemistry , epoxide , toxicokinetics , excretion , pharmacology , biochemistry , biology , enzyme , organic chemistry , catalysis , copolymer , polymer

The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.

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