Pulmonary response to polyurethane dust. | Zendy

Klaus L. Stemmer | Zendy; Eula Bingham | Zendy; W. Emmett Barkley | Zendy

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Pulmonary response to polyurethane dust.

Author(s) -

Klaus L. Stemmer,

Eula Bingham,

W. Emmett Barkley

Publication year - 1975

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.7511109

Subject(s) - weanling , scars , fibrosis , pathology , lung , intratracheal instillation , inflammatory response , bronchus , inflammation , medicine , pulmonary fibrosis , polyurethane , gastroenterology , physiology , chemistry , respiratory disease , bronchoalveolar lavage , organic chemistry

Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.

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