No evidence of dioxin cancer threshold. | Zendy

D.P. Mackie | Zendy; Junfeng Liu | Zendy; YeongShang Loh | Zendy; Valerie M. Thomas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

No evidence of dioxin cancer threshold.

Author(s) -

D.P. Mackie,

Junfeng Liu,

YeongShang Loh,

Valerie M. Thomas

Publication year - 2002

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.5730

Subject(s) - extrapolation , weighting , statistics , population , risk assessment , cancer , toxicology , environmental health , environmental science , medicine , mathematics , biology , computer science , computer security , radiology

The U.S. Environmental Protection Agency (EPA) has developed an estimate of the human cancer risk from dioxin, using the standard low-dose linear extrapolation approach. This estimate has been controversial because of concern that it may overestimate the cancer risk. An alternative approach has been published and was presented to the U.S. EPA Science Advisory Board's Dioxin Review Panel in November 2000. That approach suggests that dioxin is a threshold carcinogen and that the threshold is an order of magnitude above the exposure levels of the general population. We have reexamined the threshold analysis and found that the data have been incorrectly weighted by cohort size. In our reanalysis, without the incorrect weighting, the threshold effect disappears.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research