Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice | Zendy

Joseph D. Latoche | Zendy; Alexander C. Ufelle | Zendy; Fabrizio Fazzi | Zendy; Koustav Ganguly | Zendy; George D. Leikauf | Zendy; Cheryl L. Fattman | Zendy

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Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice

Author(s) -

Joseph D. Latoche,

Alexander C. Ufelle,

Fabrizio Fazzi,

Koustav Ganguly,

George D. Leikauf,

Cheryl L. Fattman

Publication year - 2016

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1510335

Subject(s) - hydroxyproline , bronchoalveolar lavage , estrogen receptor , ovariectomized rat , lung , fibrosis , endocrinology , medicine , estrogen , pulmonary fibrosis , osteopontin , biology , cancer , breast cancer

Fibrotic lung diseases occur predominantly in males, and reports describe better survival in affected females. Male mice are more sensitive to silica-induced lung fibrosis than silica-treated female mice. Secreted phosphoprotein 1 (SPP1, also known as osteopontin) increases in pulmonary fibrosis, and Spp1 transcription may be regulated by estrogen or estrogen receptor-related receptors.

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