Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Author(s) -
Martyn T. Smith,
Kathryn Z. Guyton,
Catherine F. Gibbons,
Jason M. Fritz,
Christopher J. Portier,
Ivan Rusyn,
David M. DeMarini,
Jane C. Caldwell,
Robert J. Kavlock,
Paul F. Lambert,
Stephen S. Hecht,
John R. Bucher,
Bernard W. Stewart,
Robert A. Baan,
Vincent James Cogliano,
Kurt Straíf
Publication year - 2015
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1509912
Subject(s) - international agency , carcinogen , carcinogenesis , cancer , computational biology , bioinformatics , medicine , computer science , biology , genetics
A recent review by the International Agency for Research on Cancer (IARC) updated the assessments of the > 100 agents classified as Group 1, carcinogenic to humans (IARC Monographs Volume 100, parts A-F). This exercise was complicated by the absence of a broadly accepted, systematic method for evaluating mechanistic data to support conclusions regarding human hazard from exposure to carcinogens.
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