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A recent review by the International Agency for Research on Cancer (IARC) updated the assessments of the &gt; 100 agents classified as Group 1, carcinogenic to humans (IARC Monographs Volume 100, parts A-F). This exercise was complicated by the absence of a broadly accepted, systematic method for evaluating mechanistic data to support conclusions regarding human hazard from exposure to carcinogens.

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis