Open AccessEffects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice
Author(s) -
Gregory J. Smith,
Joseph A. Cichocki,
Bennett Doughty,
José E. Manautou,
SvenEric Jordt,
John B. Morris
Publication year - 2016
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1509851
Subject(s) - acetaminophen , oxidative stress , pharmacology , respiratory tract , npsh , medicine , tobacco smoke , respiratory system , anesthesia , chemistry , glutathione , biochemistry , environmental health , enzyme
Although it is known that acetaminophen causes oxidative injury in the liver, it is not known whether it causes oxidative stress in the respiratory tract. If so, this widely used analgesic may potentiate the adverse effects of oxidant air pollutants.