Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment | Zendy

Katie M. O’Brien | Zendy; Kristen Upson | Zendy; Nancy R. Cook | Zendy; Clarice R. Weinberg | Zendy

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Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment

Author(s) -

Katie M. O’Brien,

Kristen Upson,

Nancy R. Cook,

Clarice R. Weinberg

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1509693

Subject(s) - creatinine , covariate , confidence interval , biomarker , urine , urinary system , statistics , confounding , standard error , chemistry , medicine , physiology , mathematics , biochemistry

Investigators measuring exposure biomarkers in urine typically adjust for creatinine to account for dilution-dependent sample variation in urine concentrations. Similarly, it is standard to adjust for serum lipids when measuring lipophilic chemicals in serum. However, there is controversy regarding the best approach, and existing methods may not effectively correct for measurement error.

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