Atmospheric Interactions and Cardiac Arrhythmias

Although plausible pathophysiological mechanisms link air pollution to arrhythmogenesis, among them altered autonomic tone, repolarization abnormalities, oxidative stress, myocardial ischemia, and increased intracardiac pressure (Link and Dockery 2010), definitive conclusions have not been reached as yet. Langrish et al. (2014) analyzed 13 double-blind randomized crossover studies and found no significant risk of arrhythmia attributable to acute controlled exposure to air pollutants. Three issues related to meteorological factors probably either confound or modify the short-term association between air pollution and cardiac arrhythmia. First, several meteorological elements, including air temperature, atmospheric pressure, relative air moisture, and wind speed and direction, also are implicated in triggering ventricular (Culic et al. 2004, 2005) and supraventricular (Culic et al. 2012, 2013) arrhythmias independent of physical and emotional stress. In the short term, those meteorological factors may facilitate arrhythmias in susceptible patients by increasing circulatory load and thromboinflammatory processes (Culic 2014). Second, these same meteorological elements substantially influence concentrations of sulfur dioxide, carbon monoxide, nitrogen dioxide, ozone, and suspended particulate matter (Bertaccini et al. 2012; Ilten and Selici 2008; Ito et al. 2007). In addition, the greatest ozone production and pollution results from stable, dry, hot weather with high atmospheric pressure and low wind (Vanos et al. 2014). Air pollution may increase human vulnerability to the effects of temperature, and temperature extremes, in turn, influence population vulnerability to air pollution (Burkart et al. 2013; Ren et al. 2006). Vanos et al. (2014) reported that cardiovascular and respiratory mortality due to short-term exposure to gaseous air pollutants was significantly modified by weather types and season. Alberdi et al. (1998) reported that both relative air moisture and air temperature are strongly related to daily mortality even after controlling for air pollution and influenza. Keatinge and Donaldson (2001) suggested that prolonged cold weather with less wind and rain may produce false associations between mortality and certain air pollutants. Finally, strong mutual interrelations exist among the above-mentioned meteorological elements. Alberdi et al. (1998) pointed out the strong inverse association they observed between relative air moisture and air temperature as an important problem for regression analysis. Langrish et al. (2014) caution against definitive acceptance of air pollution as an independent trigger of cardiac arrhythmias. However, the studies included in their analysis had no data on meteorological factors. It is likely that interactive effects among air pollutants and meteorological elements bias each other’s association with arrhythmias and other acute cardiac events. Therefore, further research of the health effects of atmospheric factors should continue in order to identify potentially harmful influences for the population as whole as well as for its vulnerable subgroups.