Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[ a ]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b ]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens | Zendy

Rhian David | Zendy; Timothy M. D. Ebbels | Zendy; Nigel J. Gooderham | Zendy

Open Access

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[ a ]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b ]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens

Author(s) -

Rhian David,

Timothy M. D. Ebbels,

Nigel J. Gooderham

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1409557

Subject(s) - benzo(a)pyrene , carcinogen , chemistry , genotoxicity , mutagen , pyrene , flow cytometry , cell cycle , microbiology and biotechnology , biochemistry , toxicity , apoptosis , biology , organic chemistry

Chemical carcinogens such as benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may contribute to the etiology of human diet-associated cancer. Individually, these compounds are genotoxic, but the consequences of exposure to mixtures of these chemicals have not been systematically examined.

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