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Chemical carcinogens such as benzo[a]pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may contribute to the etiology of human diet-associated cancer. Individually, these compounds are genotoxic, but the consequences of exposure to mixtures of these chemicals have not been systematically examined.

environmental health perspectives

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[ <i>a</i> ]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5- <i>b</i> ]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[ a ]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b ]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens