Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners | Zendy

Shuguang Leng | Zendy; Clément Thomas | Zendy; Amanda M. Snider | Zendy; Maria A. Picchi | Zendy; Wenshu Chen | Zendy; Derall G. Willis | Zendy; Teara G. Carr | Zendy; Jacek Krzeminski | Zendy; Dhimant Desai | Zendy; Amin Shantu | Zendy; Yong Lin | Zendy; Marty R. Jacobson | Zendy; Steven A. Belinsky | Zendy

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Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners

Author(s) -

Shuguang Leng,

Clément Thomas,

Amanda M. Snider,

Maria A. Picchi,

Wenshu Chen,

Derall G. Willis,

Teara G. Carr,

Jacek Krzeminski,

Dhimant Desai,

Amin Shantu,

Yong Lin,

Marty R. Jacobson,

Steven A. Belinsky

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1409437

Subject(s) - lung cancer , single nucleotide polymorphism , risk factor , medicine , lung cancer susceptibility , oncology , biology , cancer research , immunology , genetics , gene , genotype

High radon exposure is a risk factor for squamous cell carcinoma, a major lung cancer histology observed in former uranium miners. Radon exposure can cause oxidative stress, leading to pulmonary inflammation. Interleukin-6 (IL-6) is a pro-carcinogenic inflammatory cytokine that plays a pivotal role in lung cancer development.

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