Identification of Microcystis aeruginosa Peptides Responsible for Allergic Sensitization and Characterization of Functional Interactions between Cyanobacterial Toxins and Immunogenic Peptides | Zendy

Esmond Geh | Zendy; Debajyoti Ghosh | Zendy; Melanie C. McKell | Zendy; Armah A. de la Cruz | Zendy; Gerard N. Stelma | Zendy; Jonathan A. Bernstein | Zendy

Open Access

Identification of Microcystis aeruginosa Peptides Responsible for Allergic Sensitization and Characterization of Functional Interactions between Cyanobacterial Toxins and Immunogenic Peptides

Author(s) -

Esmond Geh,

Debajyoti Ghosh,

Melanie C. McKell,

Armah A. de la Cruz,

Gerard N. Stelma,

Jonathan A. Bernstein

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1409065

Subject(s) - microcystis aeruginosa , microcystin , microbiology and biotechnology , immunogenicity , toxin , chemistry , peptide , biology , cytotoxicity , antigen , biochemistry , cyanobacteria , immunology , bacteria , in vitro , genetics

The cyanobacterium species Microcystis aeruginosa produces microcystin and an array of diverse metabolites believed responsible for their toxicity and/or immunogenicity. Previously, chronic rhinitis patients were demonstrated to elicit a specific IgE response to nontoxic strains of M. aeruginosa by skin-prick testing, indicating that cyanobacteria allergenicity resides in a non-toxin-producing component of the organism.

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