Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene–Pesticide Interactions in a Case–Control Study of Parkinson’s Disease, California (USA) | Zendy

Kimberly C. Paul | Zendy; Janet S. Sinsheimer | Zendy; Shan Rhodes | Zendy; Myles Cockburn | Zendy; Jeff M. Bronstein | Zendy; Beate Ritz | Zendy

Open Access

Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene–Pesticide Interactions in a Case–Control Study of Parkinson’s Disease, California (USA)

Author(s) -

Kimberly C. Paul,

Janet S. Sinsheimer,

Shan Rhodes,

Myles Cockburn,

Jeff M. Bronstein,

Beate Ritz

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408976

Subject(s) - nos1 , single nucleotide polymorphism , paraoxonase , genotype , organophosphate , nitric oxide synthase , odds ratio , biology , tetrahydrobiopterin , genetics , nitric oxide , medicine , pesticide , gene , endocrinology , oxidative stress , ecology

Nitric oxide synthase (NOS) genes are candidates for Parkinson's disease (PD) because NOS enzymes produce nitric oxide (NO), a pro-oxidant that can damage neurons. Widely used organophosphate (OP) pesticides can induce oxidative stress and are reported to increase PD risk. Additionally, two single nucleotide polymorphisms (SNPs) from the PON1 (paraoxonase 1) gene influence the ability to metabolize OPs.

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