Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants | Zendy

Mildred Maisonet | Zendy; Antonia M. Calafat | Zendy; Michele Marcus | Zendy; Jouni J. K. Jaakkola | Zendy; Hany Lashen | Zendy

Open Access

Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants

Author(s) -

Mildred Maisonet,

Antonia M. Calafat,

Michele Marcus,

Jouni J. K. Jaakkola,

Hany Lashen

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408847

Subject(s) - perfluorooctanoic acid , testosterone (patch) , endocrinology , medicine , sex hormone binding globulin , perfluorooctane , interquartile range , physiology , chemistry , androgen , hormone , biochemistry , sodium , organic chemistry , sulfonate

Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research