Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential | Zendy

Matias S. AtteneRamos | Zendy; Ruili Huang | Zendy; Sam Michael | Zendy; Kristine L. Witt | Zendy; Ann M. Richard | Zendy; Raymond R. Tice | Zendy; Anton Simeonov | Zendy; Christopher P. Austin | Zendy; Menghang Xia | Zendy

Open Access

Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential

Author(s) -

Matias S. AtteneRamos,

Ruili Huang,

Sam Michael,

Kristine L. Witt,

Ann M. Richard,

Raymond R. Tice,

Anton Simeonov,

Christopher P. Austin,

Menghang Xia

Publication year - 2014

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408642

Subject(s) - mitochondrion , viability assay , adenosine triphosphate , inner mitochondrial membrane , biochemistry , biology , chemistry , pharmacology , computational biology , cell

Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases.

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