Effects of Atrazine on Estrogen Receptor α – and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts | Zendy

Lidia Albanito | Zendy; Rosamaria Lappano | Zendy; Antonio Madeo | Zendy; Adele Chimento | Zendy; Eric R. Prossnitz | Zendy; Anna Rita Cappello | Zendy; Vincenza Dolce | Zendy; Sergio Abonante | Zendy; Vincenzo Pezzi | Zendy; Marcello Maggiolini | Zendy

Open Access

Effects of Atrazine on Estrogen Receptor α – and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts

Author(s) -

Lidia Albanito,

Rosamaria Lappano,

Antonio Madeo,

Adele Chimento,

Eric R. Prossnitz,

Anna Rita Cappello,

Vincenza Dolce,

Sergio Abonante,

Vincenzo Pezzi,

Marcello Maggiolini

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408586

Subject(s) - gper , estrogen receptor , atrazine , cancer cell , cancer research , signal transduction , biology , estrogen receptor alpha , microbiology and biotechnology , gene silencing , mapk/erk pathway , cancer , chemistry , biochemistry , breast cancer , gene , genetics , pesticide , agronomy

The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells. The G protein estrogen receptor (GPR30/GPER) has been reported to be involved in certain biological responses to endogenous estrogens and environmental compounds exerting estrogen-like activity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research