Developmental Exposure to a Commercial PBDE Mixture: Effects on Protein Networks in the Cerebellum and Hippocampus of Rats | Zendy

Prasada Rao S. Kodavanti | Zendy; Joyce E. Royland | Zendy; Cristina Osorio | Zendy; Witold Winnik | Zendy; Pedro A. Ortiz | Zendy; Lei Lei | Zendy; Ram Ramabhadran | Zendy; Óscar Álzate | Zendy

Open Access

Developmental Exposure to a Commercial PBDE Mixture: Effects on Protein Networks in the Cerebellum and Hippocampus of Rats

Author(s) -

Prasada Rao S. Kodavanti,

Joyce E. Royland,

Cristina Osorio,

Witold Winnik,

Pedro A. Ortiz,

Lei Lei,

Ram Ramabhadran,

Óscar Álzate

Publication year - 2014

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408504

Subject(s) - cerebellum , hippocampus , polybrominated diphenyl ethers , oxidative stress , biology , signal transduction , endocrinology , medicine , central nervous system , chemistry , microbiology and biotechnology , ecology , pollutant

Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and peripheral (motor dysfunction) neurotoxic effects at concentrations/doses similar to those of PCBs. The cellular and molecular mechanisms for these neurotoxic effects are not fully understood; however, several studies have shown that PBDEs affect thyroid hormones, cause oxidative stress, and disrupt Ca2+-mediated signal transduction. Changes in these signal transduction pathways can lead to differential gene regulation with subsequent changes in protein expression, which can affect the development and function of the nervous system.

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