Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells | Zendy

Shan Whirledge | Zendy; Linda T. Senbanjo | Zendy; John A. Cidlowski | Zendy

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Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells

Author(s) -

Shan Whirledge,

Linda T. Senbanjo,

John A. Cidlowski

Publication year - 2014

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408437

Subject(s) - genistein , endocrinology , glucocorticoid receptor , medicine , signal transduction , glucocorticoid , receptor , biology , chemistry , microbiology and biotechnology

The link between environmental estrogen exposure and defects in the female reproductive tract is well established. The phytoestrogen genistein is able to modulate uterine estrogen receptor (ER) activity, and dietary exposure is associated with uterine pathologies. Regulation of stress and immune functions by the glucocorticoid receptor (GR) is also an integral part of maintaining reproductive tract function; disruption of GR signaling by genistein may also have a role in the adverse effects of genistein.

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